There is much buzz about this Supplement. The Background History of Laminine™

The Background History of
Laminine™



WHAT IS Laminine™?


When we started down the path of looking to provide its
customers a solid, proven nutritional supplement to aid the
brain in regulating the body and build a stronger body, we
searched for an amino acid and
oligopeptide combination which had all the required nourishment
for the task at hand.

We found numerous studies for the cause
and effect of individual amino acids, peptides and hormones, not
to mention an equal number of products touting high dosages of
one over another as beneficial for consumption. What was not
clear was how many companies had developed and proven the right
“combination” of amino acids,
peptides, and growth factors required? It didn’t surprise us
to find there were none. So we embarked on our own research
project. We looked for a balanced amino acid/peptide blend in
nature, which could meet our needs with minimal additions.

That is when we discovered that in 1929 a Canadian doctor, Dr.
John Ralston Davison, theorized that an injected extract from
fertilized hen eggs could be helpful for a number of his cancer
patients. In fact, he spent well over a decade developing and
researching his theory. However, when Dr. Davidson passed away
in 1943, his research on fertilized hen eggs quickly and quietly
came to a halt and was lost.

It wasn’t until almost 50 years later that the pursuit of fertilized hen egg extract was revived by Norway’s foremost expert on egg research, Dr. Bjodne Eskeland.

Dr. Eskeland also hypothesized that partially incubated,
fertilized hen eggs contained a special combination of amino
acids, peptides, and protein fractions that could help provide
an incredible array of health benefits when consumed by humans.
In theory, these partially incubated, fertilized eggs –
specifically 9-day-old fertilized eggs, contain all the
nutrients required to start a new life. This includes vitamins,
minerals and proteins, as well as important defense factors,
growth factors, hormones and other biologically active
components. While not much was known about the growth factor at
the time, the high level of oligopeptides (small peptides) gave
credence to research we had done on the necessity of rapid
transport across the digestive membrane in order to derive
effective benefits from amino acids.

We felt this could be the best “base” ingredient for our
formulation.
Laminine™’s parent company, Lifepharm®, Looked into
what was being done with this key ingredient that had so many
benefits.
They contacted the team of scientists in Norway
working with it and now have exclusive rights for distribution
and have it manufactured exclusively for us at Laminine™™.

A patented process extracts the critical nutritional fluid from
the white of an egg at the protoembryonic stage, so we called it
ProtoEmbryonic Stage Extract (PESE). The extract not only
provided a mechanism of rapid transport of very critical
nutrients, but also contained Basic Fibroblast Growth Factor,
which is most probably responsible for the amino acids and
peptides to be utilized in the right manner, by “directing”
their correct use by the body. The growth factor is also
responsible for nurturing the body’s own stem cells both
differentiated, and undifferentiated. Common amino acid
formulations do not contain this growth factor, and may not be
utilized by the brain in the most efficient manner.

Our team of scientists lead by Dr. Alex Martin, a leading doctor
in the study of nutritional supplements, at the Lifepharm®
institute of technology went to work to develop the perfect
supplement. Using PESE as a base ingredient, we looked at the
symptoms caused most by our diets and environment and then
looked to “super charge” the PESE for modern day use. Skin and
hair health, moods (depression), memory loss, fatigue and
cardiovascular health are most affected by today’s lifestyle.
These individual symptoms and how Laminine™ addresses them are
covered later in this booklet.

Having a perfectly balanced, natural, transport mechanism, with
a strong “director” with PESE we knew that we were assured
that the added amino acids will not only find their way to the
right areas of the body, but will be guided properly to perform
their function efficiently. We then added the amino acids most
critical for the health of your skin, hair, memory function,
cardiovascular health and restoration of energy, from natural
plant protein and marine protein. These ingredients from land,
sea, and sky combine to form the powerful symbiotic relationship
of our base ingredient in Laminine™ we call OPT9.

SPORTS NUTRITION

OPT9 and creatine reinforce each other. The net result of using
this combination is improved performance, decreased fatigue, and
a reduced risk of energy depletion in the muscles.

In 1996, a double-blind trial on the use of PESE conducted at
the University of Colorado showed that the group using it
experienced a strength increase that was nearly double that of
the group using creatine. PESE and creatine together were found
to outperform creatine and other food supplements in the areas
of endurance, training, motivation, and subjective health and
well-being, and it has the enthusiastic endorsement of many top
athletes. They report recovering faster after training. This is
linked to a substantial reduction in lactic acid production,
which also contributes to increased stamina.

But what does creatine have to do with OPT9? It appears that
creatine and the egg protein fractions that are found in OPT9
reinforce each other, resulting in a prominent increase in
effectiveness. This means that bodybuilders and athletes
experience greatly enhanced benefits when adding Laminine™ to
their regimen. No
wonder the product has the enthusiastic endorsement of so many
professional athletes and bodybuilders.

Whether it is a physical or mental challenge you face or just
the need to handle everyday demands, Laminine™™ may help.
Benefits
may include:

1. A delay in lactic acid production
2. The ability to tolerate longer training sessions.
3. Improved Stamina
4. Maximum Muscular Strength
5. Faster Recovery after training sessions
6. Quicker recovery from physical exertion
7. Better muscle tone
8. Increased muscle strength

MEMORY ENHANCEMENT

The most pronounced effect of artificial sweeteners and MSG in
the body is to interfere with this synergistic performance. We
therefore decided to address this issue when we created
Laminine™.

Memory function is controlled by a well-balanced joint effect of
Glutamate and Glycine. Both these amino acids act together to
play a critical role in the ability of two neurons to connect,
an important cellular mechanism for learning and memory to take
place. PESE is low in these amino acids. Therefore, Laminine™
enhances these levels in OPT9 by the addition of an isolated
vegetable protein to provide extra glutamic acid and with marine
protein extract to provide extra Glycine. PESE is used to
provide additional FGF in the aid of memory. FGF is known to
build neurites, the bridges between the neurons and the eceptors/transmitters
of signals. Research shows FGF also inhibits and destroys mutant
protein genes, in this case, quite possibly blocking the genes
responsible for memory loss.

In 1962, it was discovered that that neuro stem cells reside in
certain parts of the brain, where there is a malfunction. It is
also proven that FGF feeds and nurtures these stem cells to help
the healing of these malfunctions and any scarred tissue.
Lately, compelling arguments have been made to inject FGF
directly to cure Huntington’s disease, Schizophrenia, OCD and
Autism.

The synergistic effect of building the neurites, nurturing the
stem cells, having the most relevant amino acids and factors to
guide where the amino acids go, makes Laminine™ perform extremely
well in memory
enhancement.

Another very effective combination in Laminine™ is the two
ingredients Leucine and Isoleucine.
This
combination in increased by combining the PESE and the vegetable
protein extract. Leucine and Isoleucine provide ingredients for
the manufacturing of many essential biochemical components in
the body, some of which are utilized to stimulate the upper
brain and help you to be more alert and focused.

It’s no wonder we have had reports of many positive effects of
Laminine™ with people suffering from Alzheimer’s syndrome, ADD,
and a general increased memory and mental focus in our busy
lives.

MOOD ENHANCEMENT AND DEPRESSION

Depression is caused by many external factors, including stress.
In the brain, the serotonin uptake and release mechanism is
affected. Laminine™™ contains the amino acid Lysine; derived from PESE and vegetable proteins. The combination of these two
components delivers a higher level of Lysine in the OPT9 than
either ingredient would by itself. Lysine is known to regulate
serotonin levels in the brain.

Some 20 million people worldwide experience depression serious
enough to warrant being placed on prescription medication. Many,
an estimated 16 to 30 percent, who take such drugs experience
sexual dysfunction as a side effect. Some medical experts
believe the true number of people experiencing this side effect
may be as high as 78 percent due to the fact that the condition
often goes unreported by patients. Clinical studies have shown
that Laminine™ may be beneficial in enhancing libido among those
taking antidepressants.

Many people taking Laminine™ report a pronounced improvement in
their mood and an increased ability to manage stress on a daily
basis. A greater overall engage with others and desire to
accomplish things.

CARDIOVASCULAR HEALTH AND LIBIDO ENHANCEMENT

The PESE and Vegetable proteins provide a very potent dose of
Arginine. Arginine is a precursor of nitric oxide and plays a
vital role in a variety of biological processes. The inner
lining of blood vessels uses nitric oxide to signal the
surrounding smooth muscle to relax, thus resulting in increased
blood flow. Effects include modulation of the hair cycle, and
increased libido. Nitric oxide is also known for growth hormone
formation, increasing defense of the organs against effects of
aging.




REMOVING
TOXINS FROM THE BODY

PESE contains Cysteine, which is a precursor to glutathione, a
powerful antioxidant, receiving much attention nowadays for
healthier looking skin. Antioxidants fight free radicals,
harmful compounds in
the body that damage cell membranes and DNA. Free radicals occur
naturally in the body, but environmental toxins (including
ultraviolet light, radiation, cigarette smoking, and air
pollution) can increase the number of these damaging particles.
Free radicals are believed to play a role in aging as well as
the development of a number of health problems, including heart
disease and cancer.

NAC (N-Acetyl-Cysteine) is a powerful anti-oxidant and can help
prevent side effects caused by drug reactions and toxic
chemicals, and helps break down mucus in the body. It appears to
have benefits in
treating some respiratory conditions, such as bronchitis and
COPD. This is very crucial for the body’s life functions, as
NAC helps the body neutralize toxins, heavy metals, such as
mercury from dental amalgam fillings, cadmium and lead from
paint and cigarette smoke. The Sulfhydryl balance has also been
linked to enhance resistance to viral infections. NAC is one of
the most effective oral chelating agents.
Taken regularly over a period of time, NAC will remove
many toxic heavy metals from the body. NAC has been shown to be
a protective agent in many diseases and conditions in which free
radicals play a role. This includes cancer, AIDS, cirrhosis, as
well as pollution damage from smoking or other chemicals.

The added potent dose of Glycine, from our marine protein,
further enhances the anti aging effect of glutathione in the
body. Glycine from the marine protein also builds collagen,
making the skin look
healthier and less wrinkled.

Hair is composed from protein. L-Cysteine is an amino acid that
is known to promote hair growth.
It
improves hair quality and texture, and it is known to double the
length of hair. L-Cysteine also prevents
hair from falling out, and it has a detoxifying effect in the
body. The PESE and Vegetable proteins also provide a very potent
dose of Arginine. Arginine is a precursor of nitric oxide and
these effect the modulation of the hair cycle.

SKIN, HAIR, & HEALTH

We have added an additional component to OPT9 in Laminine™. The
added potent dose of Glycine, from our marine protein, further
enhances the anti aging effect of glutathione in the body.
Glycine from the marine
protein also builds collagen, making the skin look healthier and
less wrinkled.

Hair is composed from protein. L-Cysteine is an amino acid that
is known to promote hair growth.
It
improves hair quality and texture, and it is known to double the
length of hair. L-Cysteine also prevents
hair from falling out, and it has a detoxifying effect in the
body. The PESE and Vegetable proteins also provide a very potent
dose of Arginine. Arginine is a precursor of nitric oxide and
these effect the modulation of the hair cycle.

THE LECITHIN CONNECTION AND CONTROLLING CHOLESTEROL

Years ago, pioneering nutritionist Adelle Davis recognized the
error in the assumption that eating cholesterol-rich foods
causes a buildup of cholesterol in the arteries and leads to
heart disease. She taught
that a ‘cousin of the fat family’, lecithin, plays a vital
role in controlling blood cholesterol levels. Lecithin, found in
the human body (and concentrated in the brain), is a fat
emulsifier that breaks down cholesterol, preventing its buildup
in the body, Lecithin is also found in eggs. While they may
provide cholesterol, they also provide the lecithin needed to
break cholesterol down.

FATIGUE & ENERGY

Laminine™ combines the two ingredients Leucine and Isoleucine
(known as branched chain amino acids) from the PESE with an
added dose from the vegetable protein extract. Leucine and
Isoleucine provide ingredients for the manufacturing of other
essential biochemical components in the body, some of which are
utilized for the production of energy, stimulants to the upper
brain and helping you to be more alert.

Many people today are seriously energy deficient, experiencing
fatigue to some degree, Fatigue is a symptom that accompanies
most illnesses, both acute and chronic: it is often an early
warning sign that serious health problems are in the process of
developing. Persistent, extreme fatigue may be a sign of chronic
fatigue syndrome. The Center for Disease Control (CDC) estimates
that chronic fatigue syndrome affects between 100,000 and
250,000 people in the United States, but many researchers believe that the disorder is much more
prevalent than that. What is certain is that there are many
tired people everywhere
struggling to get through each day.

Whether you’re a professional athlete or a weekend warrior,
you could probably use more energy, who wouldn’t want to feel
more energetic, in order to better face the challenges, both
physical and mental, in
life. Those whose work demands mental concentration are being
sapped of energy just like those who have physically demanding
jobs. Whether the task at hand is a tennis match or a chess
tournament, increased
energy and stamina can lead to a better outcome.

STRESS MANAGEMENT & IMPROVED SLEEP

Use of Laminine™ promotes a feeling of relaxation effect that
may be to some degree attributed to the dramatic decrease in
levels of the stress hormone cortisol produced after Laminine™™’s
ingestion.
As indicated, Laminine™ reduces stress-hormone levels dramatically
in the body.
When cortisol levels decline, we feel more relaxed.
Studies show that virtually everyone who uses Laminine™ experiences a greater sense
of relaxation and with it, many extra benefits, such as improved
sleep.

Elevated levels of stress hormones not only make us feel on
edge, but also predispose us to a number of stress-related
diseases, which include serious conditions such as hypertension,
heart disease, stroke, asthma, irritable bowel syndrome,
ulcerative colitis, eczema, and autoimmune disorders. By
managing stress-hormone levels, we may be helping to prevent or
manage these disorders.

HOW DOES Laminine™ WORK & WHAT'S IN IT?

What does Opt9 Contain?

OPT9 contains a natural combination of nutrients, including
amino acids, glycopeptides, and oligopeptides that come from
fertilized eggs, isolated plant proteins, and marine elements
that work together to form a super food for the mind and body.

The Health Benefits of Laminine™™

Laminine™ has a variety of potential health benefits,
including, strength, stamina, increased libido, and sense of
well being.
These various effects may all be related to the significant
reduction of the stress hormone cortisol (by about 50 percent)
after the ingestion of Laminine™.

What exactly is PESE, and how much is known about its
benefits?

Proto Embryonic Stage Extract is the name we have given the
ingredient in Laminine™ that is derived from the partially
incubated (9 days) fertilized hen eggs. PESE contains the most
potent and balanced combination of not only amino acids, but
also other known (and unknown) factors such as Fibroblast Growth
Factor. We believe amino acids derived from such fluids combined
with the growth factors are able to enhance brain function because they are “precisely”
engineered to support the most complex stage of birth of a
living creature, the beginning. This beginning is the most
critical stage in our development just like the take off is the
most complex function in flying an airplane, or the foundation
in construction is the most essential function in the life of a
building.

The health benefits of the hen egg have been known for
centuries. Recently, further investigation of the mechanism of
the development of an embryo in an egg during incubation
revealed the scientific equivalent of the “miracle of life”.
The potency of the nutrients available to the embryo at the
latter stage of development stage has always been assumed to be
high, but it was only recently that the chemical structure of
the original egg solids for these critical stages was obtained.
During this stage oligopeptides with small
molecular weights were identified. These short chains of amino
acids are able to cross the digestive barrier without breaking
down or changing the ratios and proportions. Peptides are far
more potent than other neurotransmitters, requiring only small
amounts to produce a profound effect.

Additionally, the uptake of the Fibroblast Growth Factor (FGF)
(present in PESE) by the embryo sharply increases and the FGF
present have been isolated through a patented process precisely
at the right stage of incubation, extracted and freeze dried to
bring the “miracle of life” benefits to humans.

Extracting PESE before the peptides and FGF are “used up” to
build organs and bones, allows us to provide this building,
repairing, maintenance mechanism of perfectly balanced amino
acids, peptides and growth factors to humans. While virtually
unknown in the

United States

until very recently, PESE has been marketed successfully as a
nutritional supplement in
Scandinavia
for many years.

How is FGF helpful to humans?

The precise blend of oligopeptides may be seen as building
blocks, without a bridge, or a director.
The
role of such a director is fulfilled by a growth factor known as
the Fibroblast Growth Factor, or FGF. FGF is prolific in PESE, as well as in the human placenta.
A detailed day-by-day study was performed in 1988.
Discovered
only in the seventies, and also a peptide, this FGF is critical
in the development of embryos, including humans. However, it is
not found to be circulating in the human adult bodies. FGF is
responsible for building the linings in the blood vessels,
creating the infrastructure for the nutrients to flow to
critical areas of the brain and organs. Research credits FGF
with the potential to directly affect many neuro disorders
because of clear results of the ability of FGF to affect the
growth of neurites. Neurites are signal senders (Axons) and
signal receivers (dendrites) attached to the brain neurons.

Research has also shown clearly that new cell cultures show a
dramatic increase in peptide and amino acid uptake in the
presence of FGF. This result gives credence to the hypothesis
that embryonic growth is
influenced by a very precise mechanism, which combines unique
combinations of amino acids, peptides and FGF.

Since FGF is not circulating in adults, multiple research
projects on the effects of FGF serums to cure neuro disorders
have been carried out. Fundamental to the research is the fact
discovered by Altman, J.
in 1962 that neural STEM cells are formed by the body in
response to abnormalities, and are resident in certain zones of
the brain. The brain is therefore ready to repair the damage,
and these cells have
shown to differentiate into a wide range of neurons. Neurons
derived from such neural stem cells are capable of migrating to
various regions of the Central Nervous System.

Use of vegetable proteins

Vegetable protein has an essential amino acid profile, which is
very close to that of the ideal protein for human nutrition (FAO/WHO
1985 and 2002). For Laminine™, a patented process further
isolates these
protein’s to eliminate the compounds, which neutralize the
benefits of the essential amino acids.
The
result is an ingredient, which is high in Glutamic acid,
(further enhancing the cognitive function of
the brain), branched chain amino acids (to counter insomnia),
Lysine (to control release of serotonin, controlling moods) and
Arginine (promoting Nitric Oxide and growth hormone formation).
These specially
isolated proteins’s therefore adds a synergistically potent
composition to enhance brain activity.

Use of Marine Proteins

The high levels of Glycine in the specially extracted marine
protein used in Laminine™, combined with a significant amount of hydroxyproline to stabilize the glycine, makes it a primary
candidate for a terrific
brain food. By itself, Glycine is a neurotransmitter, primarily
utilized by the brain to control glutamate levels. As a
combination within OPT9, it becomes a powerful force to enhance
memory function in
the brain.

AMINO ACIDS AND THEIR ROLES

Amino acids are critical to life, and have many functions in
metabolism. One particularly important function is as the
building blocks of proteins, which are linear (straight) chains
of amino acids. Laminine™’s unique blend of ingredients
combines to produce a complete chain of 20 amino acids. The
following is a list of those amino acids and their potential
benefits. Amino acids are organic compounds that combine to form
proteins. When proteins are digested, amino acids are left. The
human body requires a number of amino acids to grow and
breakdown food and is a very important part of nutrition.
A complete balance of amino are contained in Laminine™ and include:

· Cystine
· Methionine
· Aspartic Acid
· Threonine
· Serine
· Glutamic Acid
· Proline
· Glycine
· Alanine
· Valine
· Isoleucine
· Leucine
· Tyrosine
· Histidine
· Ornitine
· Lysine
· Arginine, Hydroxyproline
· Ammon

Glycine
and glutamine are precursors of nucleotides. Nucleotides are
molecules that, when joined together, make up the structural
units of RNA and DNA.

These building blocks of proteins perform various vital roles in
the body and help us to remain healthy in many ways.

· Antioxidants helping with combating free radicals and
environmental toxins including ultraviolet light, radiation,
cigarette smoking, and air pollution.
· Benefits in treating some respiratory conditions, such as
bronchitis and COPD. Angina, Chronic bronchitis and Chronic
Obstructive Pulmonary Disease (COPD), Influenza, Acute
Respiratory Distress Syndrome (ARDS), HIV/AIDS.
· Reducing symptoms of asthma, cystic fibrosis, and emphysema.
· Helping to Improve or Preventing colon cancer.
· Helping to Improve or Preventing cataracts and macular degeneration.
· Helping increase HDL “good” cholesterol.
· Helping increase fertility when taken along with fertility
drugs in people with polycystic ovary disease.
· Helping improve outcome in children with advanced cerebral
adrenoleukodystrophy, a type of leukemia.
· Helping treat cocaine addiction, schizophrenia, and gambling
addictions.
· Reducing lung cancer risk among smokers.
· Decrease Cell oxidation.
· Enhances neurotransmitters in the brain.
· Assist in the formation of tooth enamel.
· Blood coagulation regulation.
· Immune response.
· Increased memory function, cognition, and voluntary movement
and learning ability.
· Aid in the elimination of toxic ammonia in the form of
nitrogen from the body.
· Improve hair and skin.
· Fight insomnia.
· Increase energy and endurance.
· Regulation of blood pressure under stress.
· Controls release of serotonin and mood improvement.
· Increased vasodilatation which increases blood flow.
· Humans with atherosclerosis, diabetes or hypertension often
show impaired Nitric Oxide pathways.

THE
ROLE OF PEPTIDES

Small amino acid chain peptides (such as those contained in
Laminine™), commonly known as oligopeptides, are very easily
transported through the intestinal, membrane. They are sometimes
used as transport mechanisms for drugs.

Peptides are short polymers formed from the linking, in a
defined order, of α-amino acids. Proteins are multi peptide
chains.

Proteins must be broken down to smaller and smaller peptides,
and eventually an amino acid, to perform its functions.
Dietary
intake of peptides and amino acids, which can reach their
destination,
therefore, can be extremely beneficial.

Peptides are the most abundant compounds in the hypothalamus of
the brain, and perform vital functions of communicating sensory
impulses to the endocrine system (hormone producing glands).

Understanding the mechanisms of the effect of peptides, and the
types of peptides, is a complex field and is being studied
extensively. Unfortunately, these studies are done in isolation
and disregard the whole picture of the many complex mechanisms
which exist in our body. Further, these studies are usually
focused on a particular amino acid, peptide or other
neurotransmitters. While the results identify the final activity
with the amino acid/peptide, the mechanism of transport of such
critical amino acid/peptides to the final destination is a
subject of major arguments. These arguments cast a shadow on the
importance of nutritional supplements. Most doctors will tell
you that nutritional supplements “cannot hurt”, but stop
short of endorsing them.
The reason is the lack of evidence that
the active ingredients have been formulated in the correct form
that can be used by the body.