Autistic, Alzheimer’s & Multiple Sclerosis Brain Tissues Have Significant Amounts of Aluminum In Them

• The Facts:
  A 2020 study found that the aluminum content in brain tissue of people with Alzheimer's disease, familial Alzheimer's disease, autism spectrum disorder and multiple sclerosis is significantly higher compared to tissues used in the study as controls.
  
• Reflect On:
  Could aluminum be playing a role in these, as well as other diseases? How does it get into our brain?
  

We have confirmed previous conclusions that the aluminum content of brain tissue in Alzheimer’s disease, autism spectrum disorder and multiple sclerosis is significantly elevated. Further research is required to understand the role played by high levels of aluminum in the aetiology of human neurodegenerative and neurodevelopmental disease.

Animal models of aluminum intoxication reproduce the neuropathologies and neurodevelopmental effects of human neurodegenerative disease, if not the diseases per se. Cell models and in vitro studies demonstrate mechanisms of aluminum toxicity known to be involved in human neurodegenerative disease. Perhaps the information that is still missing from understanding of aluminum’s role in each of the diseases compared herein is how much aluminum is too much in human brain tissue. The comparison we have made herein between control brain tissue showing no signs of neurodegenerative disease and the disease groups…is beginning to answer this question. Only further measurements on more donor brains will enable a definitive conclusion to be reached on the role played by aluminum in human neurodegenerative disease.

Once you start to see these sort of data together, once you start to see the levels of a known neurotoxic metal accumulate to these levels, it is absolutely inevitable that they will contribute to disease. – Professor Christopher Exley, lead author of the study, taken from the interview below.

We are writing to express our concern over the possible interruption of research on aluminum and disease conducted by Christopher Exley and his group in your (Keele) University. We feel that Christopher Exley’s work conducted for so many years in line with the previous research of late Pr Birchall at Keele University has been an important service to the scientific community, patients and society in Europe and globally. We firmly declare that Pr Exley has always defended rigorous research independent of commercial conflicts of interest, and has freely carried out his research without any control by any of his sponsors.