How psychedelics work, explained by Johns Hopkins professor Matthew Johnson.
Humans have been consuming psychedelic substances for millennia, but only in the past century have we made significant progress in understanding how they affect the brain and our psychology. We have learned, for example, that psychedelic drugs like psilocybin, LSD, and DMT cause psychedelic experiences primarily by affecting a particular type of serotonin receptor, while other drugs like ketamine and PCP primarily affect the glutamate system. But there remain open questions about how these biological effects contribute to profound psychological changes in people who take psychedelics. One answer seems to center on how the drugs spark communication between different brain regions. What’s more, psychedelics seem to encourage greater neuroplasticity, meaning the brain becomes primed to learn new things in the wake of a psychedelic experience. Check out this Big Think interview with Matthew Johnson, a professor of psychiatry at Johns Hopkins University who explains how psychedelics work, and what researchers hope to uncover about the substances in the future.
https://youtu.be/yS9FBB19Ws0